Inhibition of growth of tubercle bacilli by certain vitamin analogues

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by , [n.p
Bacillus tuberculosis., Vita
Statement[by] Hilda Pope and David T. Smith.
ContributionsSmith, David T. 1898-
Classifications
LC ClassificationsQR201.T6 P75
The Physical Object
Pagination34-47 p.
ID Numbers
Open LibraryOL199782M
LC Control Numbera 51004962
OCLC/WorldCa32769060

Inhibition of Growth of Tubercle Bacilli by certain Vitamin Analogues. Author(s): Pope, Hilda; Smith, D. by: 2.

Am Rev Tuberc. Jul;62(1-B) Inhibition of growth of tubercle bacilli by certain vitamin analogues. POPE H, SMITH DT. PMID: Cited by: 2. Full text Full text is available as a scanned copy of the original print version.

Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected by: 3. J Bacteriol. Jan;63(1) Growth inhibition of tubercle bacilli by analogues of biotin.

POPE H. PMCID: PMC PMID: Cited by: 3. Recent studies have shown that vitamin B1 (VB1) and vitamin C (Vc) can inhibit Mycobacterium tuberculosis growth, but the precise mechanism is still not well understood.

Crowle AJ, Ross EJ, May MH. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages.

Infect Immun. Dec; 55 (12)– [PMC free article] Crowle AJ, Salfinger M, May MH. 1,25(OH)2-vitamin D3 synergizes with pyrazinamide to kill tubercle bacilli in cultured human macrophages. Abstract. Tuberculosis is an infection of the monocytic phagocyte (MP) system.

1–8 The disease-causing bacilli multiply in cells of this system as determined by bodily environment. For example, they reproduce freely in alveolar macrophages (MP) at the beginning of human infection because these cells lack resistance, are located in oxygen-rich areas that support the oxygen needs of these.

The inhibitory media usually had a pH above 74 and reduction of the pH to 6. 8 improved the growth of small inocula of tubercle bacilli. Noninhibitory samples of plasma could be made inhibitory by adjusting the p H to a level above 7.

Vitamin B1 was estimated by the Phycomyces test in the bacteria and in the filtrate from cultures of human, bovine and avian types of the tubercle bacillus, and of BCG, grown in the synthetic medium of Sauton. The filtered medium contained from to µg.

per ml. and the dried bacilli from to µg. per Inhibition of growth of tubercle bacilli by certain vitamin analogues book. Copping. tubercle. bacillus, suggests that vitamin D supplemen-tation may have a role in prevention of tuberculosis.

The administration. inhibition of cell growth and immunomodulation [8]. The key. The strategy for using streptomycin against tuberculosis assumes that it is not effective intracellularly. But according to animal cell experiments, this is probably incorrect.

We retested this assumption with a new experimental model using cultured human macrophages infected with tubercle bacilli so that the results would be directly relevant to human disease. Vitamin D is known to suppress the intracellular growth of M tuberculosis in vitro. 55 Crowle et al 56 demonstrated that a concentration of 4 μg/mL of 1,25OHD 3 in vivo could inhibit the multiplication of virulent tubercle bacilli in cultured human macrophages.

Vitamin B12 is made by only certain prokaryotes yet is required by a number of eukaryotes such as mammals, fish, birds, worms, and Protista, including algae. The tubercle bacillus is spread via aerosolized droplets from an. rendered the bacillus susceptible to growth inhibition by ara-A, a chain-terminating adenosine analogue which is inactive.

Open Library is an open, editable library catalog, building towards a web page for every book ever published. Read, borrow, and discover more than 3M books for free. NIEMAN C. Influence of trace amounts of fatty acids on the growth of microorganisms.

Bacteriol Rev. Jun; 18 (2)– [Europe PMC free article] [Google Scholar] POPE H, SMITH DT. Inhibition of growth of tubercle bacilli by certain vitamin analogues. Am Rev Tuberc. Jul; 62 (1-B)– [Google Scholar]. Twenty three strains of Bacillus spp.

screened from Bacillus spp. isolated from soil, showed antagonistic activities in vitro towards the Penicillium digitatum pathogen, a cause of citrus fruit rot disease.

Culture supernatants from nine strains caused >80% inhibition of P.

Details Inhibition of growth of tubercle bacilli by certain vitamin analogues EPUB

digitatum growth when they were serially diluted to Volatile compounds produced by these strains also caused " Growth of Tubercle Bacilli in Monocytes from Normal and Vaccinated Rabbits \ A Proposed Mechanism of Action for Isoniazid in the Tubercle Bacillus and Other Biological Systems." American Review of Tuberculosis, 69(6), pp.

– Related. Ariëns, E. J.: Affinity and intrinsic activity in the theory of competitive inhibition. Problems and theory.

Arch. int. Pharmacodyn. 99, 32 and D. Smith: Inhibition of growth of tubercle bacilli by certain vitamin analogues. Amer. Rev. Tuberc. 62, 34–47 Buy this book on publisher's site; Reprints and Permissions; Personalised. Denis M. Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates.

Cell Immunol. serum vitamin D levels in individuals, certain ethnic. correlates with intracellular growth inhibition of MTB. multiplication of virulent tubercle bacilli in cultured human.

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macrophages. Drea WF. Growth Inhibition of the H37 Strain of Human Tubercle Bacilli by betaThienylalanine and Its Prevention by Phenylalanine. J Bacteriol. Aug; 56 (2)– [PMC free article] HOLDEN JT, WILDMAN RB, SNELL EE. Growth promotion by keto and hydroxy acids and its relation to vitamin B6.

J Biol Chem. Aug; (2)– Measurement of Growth of Tubercle Bacilli by Means of a Spectrophotometer, Dissociation of the Tubercle Bacillus.

Description Inhibition of growth of tubercle bacilli by certain vitamin analogues EPUB

William Steenken Jr. 22 – First Page | PDF ( KB) Inhibition of Growth of Tubercle Bacilli by Certain Vitamin Analogues, Hilda Pope and David T.

Smith. Inhibition of tubercle bacilli in cultured human macrophages by chloroquine used alone and in combination with streptomycin, isoniazid, pyrazinamide, and two metabolites of vitamin D3. Antimicrob. Agents Chemother.

– Inhibition byRetinoic Acid ofMultiplication ofVirulent Tubercle Bacilli in Cultured HumanMacrophages ALFREDJ. CROWLE*ANDELISEJ. ROSS Webb-WaringLungInstitute andDepartmentofMicrobiology andImmunology, University ofColorado Health Sciences Center, BoxB, EastNinthAvenue, Denver, Colorado Received 13 July /Accepted 6 December 1.

Background Tuberculosis (TB) is one of the major fatal infectious diseases in the world ().It has infected one-third of the world’s population and is responsible for approximately 2 million deaths each year, mostly in developing countries ().Inapproximately million new cases of active TB was reported and million people died from the disease, most of which happened in.

Worsening drug resistance and the need for prolonged treatment in tuberculosis (TB) require innovative solutions including investigation of inexpensive, safe adjunctive immunotherapies.

L-arginine, the precursor of nitric oxide, and vitamin D recently have elucidated mycobactericidal and immunomodulatory actions against TB and are deficient in people with TB. Intriguingly, nicotinamide analogues are used to treat TB. after centuries of co‐existence with the Tubercle bacillus, humans still remain susceptible to TB disease.

1 Introduction: An Overview of Tuberculosis rather than by direct inhibition of microbial growth or microbial killing. Pharmacological drug screening may therefore show.

Bryan Tungland, in Human Microbiota in Health and Disease, Mucosal associated invariant T cells (MAITs) The MAITs are a special type of T cell that have several properties in common with innate T cells, and are characterized by an invariant T cell antigen receptor alpha-chain and restriction by the MHC-related protein, MR1 (Chua and Hansen, ).

Experimental design. A two-step optimization strategy was employed to increase the production of vitamin B12 by Bacillus megaterium through the provision of the required supplements for the synthesis of vitamin B12 (CoCl2, δ-aminolevulinic acid (ALA) and 5,6-dimethylbenzimidazole (DMB)) and the division of the fermentation process into three stages.

In addition, the incubation times of the. Since the tubercle bacillus rapidly develops resistance to the antibiotic, ethambutol and INH are given to prevent outgrowth of a resistant strain.

It must also be pointed out that the tubercle bacillus rapidly develops resistance to ethambutol and INH if either drug is used alone.The tuberculous granuloma: a mycobacterial perspective.

Mycobacterium tuberculosis infection elicits a robust immunological response, which results in an aggregation of host and mycobacterial components, otherwise referred to as a granuloma (Russell, ).Granuloma formation is commonly referred to as a host‐protective strategy to limit mycobacterial replication and prevent the spread of.NIEMAN C.

Influence of trace amounts of fatty acids on the growth of microorganisms. Bacteriol Rev. Jun; 18 (2)– [PMC free article] POPE H, SMITH DT. Inhibition of growth of tubercle bacilli by certain vitamin analogues.

Am Rev Tuberc. Jul; 62 (1-B)–